• 다양한 생명현상들의 분자진화적 연결고리를 이어주는 중요한 모델시스템인 촉수담륜동물문(Lophotrochozoa)에 속하는 해양 및 담수 무척추동물모델시스템을 이용하여 각 종들의 차세대 염기서열 분석방법(Next-generation sequencing, NGS)을 통한 전장 유전체(Whole genome) 및 전사체(transcriptome) 분석
  
• 발생과정 시 전반적인 발생메카니즘, 체절형성과정, 난할형성과정 및 재생과정 등을 분자생물학적, Cas9, multi-omics 방법을 이용한 연구
  
• 유용성 동물의 천연유용물질 활용 및 자가면역질환 치료제개발을 연구
  
• 진화발생생물학 (Evolutionary Developmental Biology, Evo-Devo)연구를 접목하여 각 종들의 유전체 비교 및 유용유전자들의 분석

Research in the Cho Lab is aimed at understanding causes and effects of evolutionary change in developmental processes. We are interested in the cellular and molecular mechanisms of development and regeneration in annelids and other closely related animals. We primarily utilize tools of experimental embryology, molecular and cellular biology and functional genomics.

Molecular animal model:

Annelid Development and the Evolution of Developmental Mechanisms (Evo-Devo)

We are interested in a broad range of problems associated with the cellular, molecular, and evolutionary basis of biological pattern formation in annelid.
Our lab has chosen to investigate a molecular animal model, such as oligochaete (Eisenia andrei, Perionyx excavatus), Leech (Hellobdella austinensis, Alboglossiphonia lata, Hirudo medicinalis), Urechis unicinctus, Sipunculus rudus.

1. Leeches (Hellobdella austinensis, Alboglossiphonia lata, Hirudo medicinalis, 거머리)
   - Experimental Embryology and Evo-Devo
   
   
2. oligochaete (Perionyx excavatus, 지렁이)
   
3. Annelid (Urechis unicinctus, 개불)
   -Experimental Embryology and Evo-Devo
   
4. Cephalopoda (Octopus minor, 낙지 )
   -Experimental Embryology and Evo-Devo
   
5. Whole Genome Project (A Chromosome-Scale Genome Assembly)
   
   • 다양한 생명현상들의 분자진화적 연결고리를 이어주는 중요한 모델시스템인 지렁이, 독실산거머리, 낙지, 돌멍게, 창고기, 해삼, 개불), 장수하늘소, 긴호랑거미를 이용하여 각 종들의 차세대 염기서열 분석방법(Next-generation sequencing, NGS)을 통한 전장 유전체(Chromosome-Scale Genome Assembly) 및 전사체(transcriptome) 분석
   • 비교유전체 (Comparative Genomics)를 통한 환경적응, Evo-Devo, 유용성분 발굴
   • 생체모사 시스템 개발 (독실산거머리, 낙지, 긴호랑거미)

1. The genome of common long-arm octopus Octopus minor. GIGAscience. (2018)  *Corresponding author
   BRIC 한빛사
   (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=55652&idauthorid=23829&ttype=0)
   
2. The developmental transcriptome atlas of the spoon worm Urechis unicinctus (Echiurida: Annelida). GIGAscience. (2018) *Corresponding author
   BRIC 한빛사
   (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=52924&idauthorid=23829&ttype=0)
   
3. Developmental biology and potential use of Alboglossiphonia lata (Annelida: Hirudinea) as an "Evo-Devo" model organism. Frontiers in Zoology. (2017) *Corresponding author
   BRIC 농수식품 성과 포커스
   (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=52221&idauthorid=23829&skin=agriff_treatise&stype=1)
   
4. Draft genome of the sea cucumber Apostichopus japonicus and genetic polymorphism among color variants. GIGAscience (2017) *Corresponding author
   BRIC 한빛사
   (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=48674&idauthorid=23829&ttype=0)​
   
5. Differential expression of conserved germ line markers, and delayed segregation of male and female primordial germ cells, in a hermaphrodite, the leech Helobdella. Molecular Biology and Evolution. (2014) 31(2):341-354. *Corresponding author BRIC 한빛사
   (https://www.ibric.org/myboard/read.php?Board=hbs_treatise&id=37834&idauthorid=23829&ttype=0)